I'm sure you've read how I feel about retinoids, in fact I just came from the doc yesterday and saw a new xray of the big bone spur that is forming on the edge of my hip socket and the absence of cartiledge in the socket. In my opinion 3 1/2 years old is way to young to be on any form of retinoids. The only way I would consider giving a 3 1/2 year old retinoids was if it were relieve a life threatening situation, then the risks may be worth the possble side effects in the future. Since as you say she is confident and making progress at her nursery I see no reason to put her on them, it would only be a temporary relief with possible long term side effects.