I have used glutathione as a nutritional supplement for almost a year now. It boosts your immune system which significantly helps in keeping a healthy body and anti-aging. I have not really noticed smoother skin, but overall, I am much healthier, and I don't think my skin has aged any faster. I do not have noticeable wrinkles on my face. My shins still have the mosaic pattern on them, and my hands still have the same wrinkling(IV). My nails are much stronger. So, overall it is good for your immune system, but I have not noticed any significant change in the skin. There are lots of great websites to check it out....I use Immunocal.