We use tazorac on the bad spots. A little dab every 5-6 weeks or so on the neck and behind the knees makes a huge difference and minimizes the risk of side effects that the oral versions have.
Otherwise, we just scrub a lot, use bleach in the bath, use a dremel on the thick callouses, and just keep it under control manually.
Our doctor has my husband trying 40% urea cream on his feet, wrapped in plastic wrap all night. I don't think it is making any difference for us, although I have heard other people say it works great for them.
Ichthyosis-en-Confetti Type 2
Husband, Nathan - 10, Elliot - 7, Oliver - 4, all affected.
I also have an unaffected daughter, age 8.
email: jennifer at confettiskin dot com
facebook - find me on "ichthyosis mommy spot" or "friends of ichthyosis"