Natalie's face used to get a leathery look before we began using urea. A Canada based company called Dermal Therapy makes an alpha-hydroxy lotion that contains 10% urea/10% lactic acid in a silk amino base...for us it's been the best source of urea we've used. Since urea draws water up to the surface of the skin, it tends to work best just after a soak in the bath. We sometimes use the Dermal Therapy AHA in conjunction with Dermal Therapy's heel care cream which is 25% urea after bath (they are getting ready to put out a 30% cream as well which they had made in the past, and we absolutely loved). Because the heel care stuff is $39 for a 14 oz jar, we use it sparingly and often reserve it just for the face and arms. After using the Dermal Therapy stuff, we occlude with Aquaphor. We find the urea helps with the itching as well...doing the Dermal Therapy/Aquaphor routine after a good exfoliation in the bath every night before bed has done wonders for sleep problems previously caused by itching. We also use Benadryl every night and don't have Nattie sleep in anything other than a 100% cotton pj. We bought some polyester jammies not long ago because they had Dora and Disney princesses, and they made her absolutely crazy with itch!
If you decide to try the Dermal Therapy, call the number on their site to place the order instead of doing it online because they'll give you a discount if you mention the ichthyosis.
Mom to three gorgeous princesses all affected with significant medical challenges, one of whom has CIE.