It's a straight 50/50 shot. Boy or girl, it doesn't matter. You just got lucky twice. And your grandkids won't be affected, either.
I have 2 affected boys, incidentally.
Ichthyosis-en-Confetti Type 2
Husband, Nathan - 10, Elliot - 7, Oliver - 4, all affected.
I also have an unaffected daughter, age 8.
email: jennifer at confettiskin dot com
facebook - find me on "ichthyosis mommy spot" or "friends of ichthyosis"