You're dealing with a dominant condition, so since neither you nor your spouse have the disorder, it is most likely a spontaneous mutation unique to Lauren. Her children, however, have a 50/50 chance of getting palmoplantar EHK.
There's a small chance that the mutation is in your eggs or your husband's sperm. Since all cells originate from the initial zygote, there's a chance that somewhere along the way one of your reproductive cells developed the mutation and it has carried through to some of the sex cells. But even if that were the case, you chances of having another affected child are still somewhere in the 1 in 100 range.
Congratulations on Lilly's impening birth! I hope you get some sleep before she arrives. Will you be attending the conference this year?
Ichthyosis-en-Confetti Type 2
Husband, Nathan - 10, Elliot - 7, Oliver - 4, all affected.
I also have an unaffected daughter, age 8.
email: jennifer at confettiskin dot com
facebook - find me on "ichthyosis mommy spot" or "friends of ichthyosis"