Did anyone else read this on the FIRST site?
(it can be found here: http://www.scalyskin.org/content.cfm?ContentID=260&ColumnID=4
"Lamellar ichthyosis/CIE - New concepts, new mutations.
This topic deals with the importance of lipids in epidermal function. Lipids are essential for all cells and for proper barrier function of the epidermis.
Many members of F.I.R.S.T. have been diagnosed with lamellar ichthyosis or CIE. Lamellar comes from the Latin word for plate, describing the plate-like scales. CIE is short for congenital (you were born with it), ichthyosiform (ichthyosis-like), erythroderma (red skin), or the condition where one is born with red, scaling skin. The scale in lamellar tends to be large and dark, while the scale in CIE tends to be small and white.
At the extreme, people with this group of diseases have the clinical findings either of lamellar or CIE. However, it has long been known that the distinction between the two is often blurred, and people can have features of both. Both are autosomal recessive diseases (the individual has a mutation in the same gene on both chromosomes) and are rare, occurring in about 1 in every 200,000 to 300,000 people.
These disorders not only have varying appearances clinically, they result from mutations in a number of different genes. The first mutation identified in these disorders was in the gene for transglutaminase type 1 (TMG1). Although mutations in this gene are found in about one-third of people with lamellar ichthyosis, they can also be seen in individuals with CIE. Since the description of transglutaminase 1 mutations, investigators in France and elsewhere have identified mutations in seven other genes that result in clinical findings of lamellar ichthyosis, CIE, and overlaps between the two.
Because almost all of these disorders are autosomal recessive, they are now being grouped into the large group of Autosomal Recessive Congenital Ichthyosis (ARCI). So, hello ARCI, goodbye lamellar and CIE. The French investigators speculate that all these gene codes for proteins are involved in a new, common pathway of lipid metabolism. If this turns out to be true, it might explain the common clinical presentations of what were thought to be two different disease types. "
So now, it's no longer LI or CIE, but ARCI?